ChloroquineV1, France, Analysis, bibRecord, 000118

Plasmodium fakiparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014

Identifieur interne : 000118 ( France/Analysis ); précédent : 000117; suivant : 000119

Plasmodium fakiparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014

Auteurs : Bécaye Fall [Sénégal] ; Marylin Madamet ; Cheikhou Camara [Sénégal] ; Rémy Amalvict [France] ; Mansour Fall [Sénégal] ; Aminata Nakoulima [Sénégal] ; Bakary Diatta [Sénégal] ; Yaya Diemé [Sénégal] ; Boubacar Wade [Sénégal] ; Bruno Pradines [France]

Source :

Emerging Infectious Diseases [ 1080-6040 ] ; 2016-05.

RBID : Hal:hal-01458381

Abstract

We successfully cultured 36 Plasmodium falciparum isolates from blood samples of 44 malaria patients admitted to the Hopital Principal de Dakar (Dakar, Senegal) during August December 2014. The prevalence of isolates with in vitro reduced susceptibility was 30.6% for monodesethylamodiaquine, 52.8% for chloroquine, 44.1% for mefloquine, 16.7% for doxycycline, 11.8% for piperaquine, 8.3% for artesunate, 5.9% for pyronaridine, 2.8% for quinine and dihydroartemisinin, and 0.0% for lumefantrine. The prevalence of isolates with reduced in vitro susceptibility to the artemisinin-based combination therapy partner monodesethylamodiaquine increased from 5.6% in 2013 to 30.6% in 2014. Because of the increased prevalence of P. falciparum parasites with impaired in vitro susceptibility to monodesethylamodiaquine, the implementation of in vitro and in vivo surveillance of all artemisinin-based combination therapy partners is warranted.

Url:

https://hal.archives-ouvertes.fr/hal-01458381

DOI: 10.3201/eid2205.151321

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000186
to stream Hal, to step Curation: 000186
to stream Hal, to step Checkpoint: 000077
to stream Main, to step Merge: 000D41
to stream Main, to step Curation: 000D41
to stream Main, to step Exploration: 000D41
to stream France, to step Extraction: 000118

Links to Exploration step

Hal:hal-01458381

Le document en format XML

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<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID">          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
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          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
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<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID">          <orgName>Institut de Recherche pour le Développement</orgName>
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              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
</tutelle>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Fall, Mansour" sort="Fall, Mansour" uniqKey="Fall M" first="Mansour" last="Fall">Mansour Fall</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440279" status="INCOMING">          <orgName>Service de Réanimation Médicale</orgName>
          <desc>            <address>              <country key="SN"></country>
            </address>
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        <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID">          <orgName>Hôpital Principal de Dakar</orgName>
          <desc>            <address>              <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine>
              <country key="SN"></country>
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            <ref type="url">http://www.hopitalprincipal.sn/</ref>
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</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Nakoulima, Aminata" sort="Nakoulima, Aminata" uniqKey="Nakoulima A" first="Aminata" last="Nakoulima">Aminata Nakoulima</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-224319" status="INCOMING">          <orgName>Service de pédiatrie</orgName>
          <desc>            <address>              <addrLine>Rte de la Corniche Est, Dakar</addrLine>
              <country key="SN"></country>
            </address>
          </desc>
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          <desc>            <address>              <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine>
              <country key="SN"></country>
            </address>
            <ref type="url">http://www.hopitalprincipal.sn/</ref>
          </desc>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Diatta, Bakary" sort="Diatta, Bakary" uniqKey="Diatta B" first="Bakary" last="Diatta">Bakary Diatta</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440279" status="INCOMING">          <orgName>Service de Réanimation Médicale</orgName>
          <desc>            <address>              <country key="SN"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-338318" type="direct"></relation>
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        <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID">          <orgName>Hôpital Principal de Dakar</orgName>
          <desc>            <address>              <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine>
              <country key="SN"></country>
            </address>
            <ref type="url">http://www.hopitalprincipal.sn/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Dieme, Yaya" sort="Dieme, Yaya" uniqKey="Dieme Y" first="Yaya" last="Diemé">Yaya Diemé</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214449" status="INCOMING">          <orgName>Laboratoire d'étude de la chimiosensibilité du paludisme</orgName>
          <desc>            <address>              <addrLine>Rte de la Corniche Est, Dakar</addrLine>
              <country key="SN"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-338318" type="direct"></relation>
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          <desc>            <address>              <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine>
              <country key="SN"></country>
            </address>
            <ref type="url">http://www.hopitalprincipal.sn/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-352262" type="direct"><org type="institution" xml:id="struct-352262" status="INCOMING">          <orgName>Fédération des laboratoires</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Wade, Boubacar" sort="Wade, Boubacar" uniqKey="Wade B" first="Boubacar" last="Wade">Boubacar Wade</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214459" status="INCOMING">          <orgName>Chefferie</orgName>
          <desc>            <address>              <addrLine>Rte de la Corniche Est, Dakar</addrLine>
              <country key="SN"></country>
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          <listRelation>            <relation active="#struct-338318" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-338318" type="direct"><org type="institution" xml:id="struct-338318" status="VALID">          <orgName>Hôpital Principal de Dakar</orgName>
          <desc>            <address>              <addrLine> 1, avenue Nelson Mandéla - B.P. 3006 - DAKAR (Sénégal)</addrLine>
              <country key="SN"></country>
            </address>
            <ref type="url">http://www.hopitalprincipal.sn/</ref>
          </desc>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199392" status="OLD">          <idno type="IdRef">123037891</idno>
          <idno type="RNSR">200817431S</idno>
          <orgName>Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes</orgName>
          <orgName type="acronym">URMITE</orgName>
          <date type="start">2008-01-01</date>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>27 Bd Jean Moulin 13385 MARSEILLE Cedex 5</addrLine>
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            </address>
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          <orgName type="acronym">IRD</orgName>
          <desc>            <address>              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
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<tutelle name="UM63" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
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</tutelle>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
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          <date type="end">2011-12-31</date>
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          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
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            <ref type="url">http://www.cnrs.fr/</ref>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.3201/eid2205.151321</idno>
<series><title level="j">Emerging Infectious Diseases</title>
<idno type="ISSN">1080-6040</idno>
<imprint><date type="datePub">2016-05</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>We successfully cultured 36 Plasmodium falciparum isolates from blood samples of 44 malaria patients admitted to the Hopital Principal de Dakar (Dakar, Senegal) during August December 2014. The prevalence of isolates with in vitro reduced susceptibility was 30.6% for monodesethylamodiaquine, 52.8% for chloroquine, 44.1% for mefloquine, 16.7% for doxycycline, 11.8% for piperaquine, 8.3% for artesunate, 5.9% for pyronaridine, 2.8% for quinine and dihydroartemisinin, and 0.0% for lumefantrine. The prevalence of isolates with reduced in vitro susceptibility to the artemisinin-based combination therapy partner monodesethylamodiaquine increased from 5.6% in 2013 to 30.6% in 2014. Because of the increased prevalence of P. falciparum parasites with impaired in vitro susceptibility to monodesethylamodiaquine, the implementation of in vitro and in vivo surveillance of all artemisinin-based combination therapy partners is warranted.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Sénégal</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Madamet, Marylin" sort="Madamet, Marylin" uniqKey="Madamet M" first="Marylin" last="Madamet">Marylin Madamet</name>
</noCountry>
<country name="Sénégal"><noRegion><name sortKey="Fall, Becaye" sort="Fall, Becaye" uniqKey="Fall B" first="Bécaye" last="Fall">Bécaye Fall</name>
</noRegion>
<name sortKey="Camara, Cheikhou" sort="Camara, Cheikhou" uniqKey="Camara C" first="Cheikhou" last="Camara">Cheikhou Camara</name>
<name sortKey="Diatta, Bakary" sort="Diatta, Bakary" uniqKey="Diatta B" first="Bakary" last="Diatta">Bakary Diatta</name>
<name sortKey="Dieme, Yaya" sort="Dieme, Yaya" uniqKey="Dieme Y" first="Yaya" last="Diemé">Yaya Diemé</name>
<name sortKey="Fall, Mansour" sort="Fall, Mansour" uniqKey="Fall M" first="Mansour" last="Fall">Mansour Fall</name>
<name sortKey="Nakoulima, Aminata" sort="Nakoulima, Aminata" uniqKey="Nakoulima A" first="Aminata" last="Nakoulima">Aminata Nakoulima</name>
<name sortKey="Wade, Boubacar" sort="Wade, Boubacar" uniqKey="Wade B" first="Boubacar" last="Wade">Boubacar Wade</name>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Amalvict, Remy" sort="Amalvict, Remy" uniqKey="Amalvict R" first="Rémy" last="Amalvict">Rémy Amalvict</name>
</region>
<name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name>
</country>
</tree>
</affiliations>
</record>

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Plasmodium fakiparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014

Plasmodium fakiparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014

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